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The titration schedule matters enormously because starting too high increases the risk of severe nausea, while titrating too slowly can delay results unnecessarily

Increased prevalence of the HFE C282Y hemochromatosis allele in women with breast cancer

These effects are often manageable, but they can become frustrating if treatment moves faster than the body can tolerate

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Methods Study design This was an investigator-initiated phase 2, prospective, parallel, double blinded, randomized, placebo-controlled, two-center trial (ClinicalTrials.gov Identifier: NCT02117661, the ECoM trial)